Abstract
Industrialization remains a cornerstone of economic transformation in developing countries, yet progress is often constrained by fragmented innovation systems, resource limitations, and institutional barriers. Open innovation offers an alternative paradigm by promoting knowledge flows across organizational and sectoral boundaries. This systematic literature review critically examines how open innovation partnership models are conceptualized, implemented, and adapted to support industrialization in low- and middle-income countries. The results demonstrate a progressive shift from linear innovation approaches to more networked, ecosystem-based configurations, with inbound, outbound, and coupled innovation strategies increasingly evident. University-industry-government (UIG) partnerships, intermediary-facilitated collaborations, and digital platforms emerge as dominant mechanisms. SMEs are pivotal actors but encounter persistent capability and resource constraints. Key enablers include institutional trust, leadership commitment, absorptive capacity, and digital infrastructure. Conversely, barriers such as weak policy coherence, infrastructural deficits, and fragmented coordination inhibit innovation outcomes. The analysis also identifies emerging trajectories, notably the integration of AI and digital technologies in innovation ecosystems and the evolving role of intermediaries. This review highlights critical research gaps, particularly the need for empirically validated frameworks and SME-centric strategies and offers insights to inform policy design and the development of inclusive, adaptive innovation systems aligned with sustainable industrialization objectives.
References
Anshari M., Almunawar M.N. (2022) Adopting open innovation for SMEs and industrial revolution 4.0. Journal of Science and Technology Policy Management, 13(2), 405–427. https://doi.org/10.1108/JSTPM-03-2020-0061
Araujo E., Araújo E., Peres S.C., Punzo L.F. (2021) An investigation into shapes and determinants of deindustrialization processes: Theory and evidence for developed and developing countries (1970–2017). EconomiA, 22(2), 129–143. https://doi.org/10.1016/j.econ.2021.03.001
Berchicci L. (2013) Towards an open R&D system: Internal R&D investment, external knowledge acquisition and innovative performance. Research Policy, 42(1), 117–127. https://doi.org/10.1016/j.respol.2012.04.017
Candi M., Kahn K.B. (2025) Comparing Outside-In, Inside-Out, and Coupled Open Innovation Knowledge Flows. Research-Technology Management, 68(3), 11–24. https://doi.org/10.1080/08956308.2025.2468129
Chesbrough H.W. (2003) Open innovation: The new imperative for creating and profiting from technology, Cambridge, MA: Harvard Business Press.
Delechat M.C.C., Melina M.G., Newiak M.M., Papageorgiou M.C., Spatafora M.N. (2024) Economic Diversification in Developing Countries: Lessons from Country Experiences with Broad-Based and Industrial Policies, Washington, D.C.: International Monetary Fund.
Dolata U. (2009) Technological innovations and sectoral change: Transformative capacity, adaptability, patterns of change: An analytical framework. Research Policy, 38(6), 1066–1076. https://doi.org/10.1016/j.respol.2009.03.006
Edobor F., Sambo-Magaji A. (2025) Small and Medium Enterprises (SMEs) and Sustainable Economic Development. In: Digital Transformation for Business Sustainability and Growth in Emerging Markets (eds. S. Dadwal, P. Kumar, R. Verma, S. Kumar), Bingley (UK): Emerald Publishing Limited, pp. 197–222.
Etzkowitz H., Leydesdorff L. (2000) The dynamics of innovation: From National Systems and “Mode 2” to a Triple Helix of university–industry–government relations. Research Policy, 29(2), 109–123. https://doi.org/10.1016/S0048-7333(99)00055-4
Ghobakhloo M., Iranmanesh M., Grybauskas A., Vilkas M., Petraitė M. (2021) Industry 4.0, innovation, and sustainable development: A systematic review and a roadmap to sustainable innovation. Business Strategy and the Environment, 30(8), 4237–4257. https://doi.org/10.1002/bse.2867
Lee S., Park G., Yoon B., Park J. (2010) Open innovation in SMEs: An intermediated network model. Research Policy, 39(2), 290–300. https://doi.org/10.1016/j.respol.2009.12.009
Michelino F., Caputo M., Cammarano A., Lamberti E. (2014) Inbound and outbound open innovation: Organization and performances. Journal of Technology Management & Innovation, 9(3), 65–82. https://doi.org/10.4067/S0718-27242014000300005
Ogink R.H., Goossen M.C., Romme A.G.L., Akkermans H. (2023) Mechanisms in open innovation: A review and synthesis of the literature. Technovation, 119, 102621. https://doi.org/10.1016/j.technovation.2022.102621
Oliveira‐Duarte L., Reis D.A., Fleury A.L., Vasques R.A., Fonseca-Filho H., Koria M., Baruque‐Ramos J. (2021) Innovation ecosystem framework directed to sustainable development goal# 17 partnerships implementation. Sustainable Development, 29(5), 1018–1036. https://doi.org/10.1002/sd.2191
Rabelo R.J., Bernus P., Romero D. (2015) Innovation Ecosystems: A Collaborative Networks Perspective. In: Proceedings of the Conference: Risks and Resilience of Collaborative Networks, October 2015 (Series: IFIP Advances in Information and Communication Technology) (eds. L.M. Camarinha-Matos, F. Benaben, W. Picard), vol. 463, Heidelberg, Dordrecht, London, New York: Springer, pp. 323–336. https://doi.org/10.1007/978-3-319-24141-8_29
Rodrik D. (2016) Premature deindustrialization. Journal of Economic Growth, 21, 1–33. https://doi.org/10.1007/s10887-015-9122-3
Saebi T., Foss N.J. (2015) Business models for open innovation: Matching heterogeneous open innovation strategies with business model dimensions. European Management Journal, 33(3), 201–213. https://doi.org/10.1016/j.emj.2014.11.002
Santos E., Carvalho M., Martins S. (2024) Sustainable enablers of knowledge management strategies in a higher education institution. Sustainability, 16(12), 5078. https://doi.org/10.3390/su16125078
Smith P.G. (2007) Flexible product development: Building agility for changing markets, New York: John Wiley & Sons.
Talaja A. (2012) Testing VRIN framework: Resource value and rareness as sources of competitive advantage and above average performance. Management – Journal of Contemporary Management Issues, 17(2), 51–64.
Watkins A., Papaioannou T., Mugwagwa J., Kale D. (2015) National innovation systems and the intermediary role of industry associations in building institutional capacities for innovation in developing countries: A critical review of the literature. Research Policy, 44(8), 1407–1418. https://doi.org/10.1016/j.respol.2015.05.004

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